CIDeRGeneral Information:
| Id: | 7,083 (click here to show other Interactions for entry) |
| Diseases: |
Nephronophthisis 13
- [OMIM]
Senior-Loken syndrome 8 - [OMIM] |
| Mus musculus | |
| article | |
| Reference: | [PMID: 22689656] |
Interaction Information:
| Comment | Two intraflagellar transport (IFT) complexes, IFT-A and IFT-B, build and maintain primary cilia and are required for activity of the Sonic hedgehog (Shh) pathway. A weak allele of the IFT-A gene, Ift144, caused subtle defects in cilia structure and ectopic activation of the Shh pathway. In contrast, strong loss of IFT-A, caused by either absence of Ift144 or mutations in two IFT-A genes, blocked normal ciliogenesis and decreased Shh signaling. In strong IFT-A mutants, the Shh pathway proteins Gli2, Sufu, and Kif7 localized correctly to cilia tips, suggesting that these pathway components were trafficked by IFT-B. In contrast, the membrane proteins Arl13b, ACIII, and Smo failed to localize to primary cilia in the absence of IFT-A. |
|
Formal Description Interaction-ID: 69600 |
complex/PPI increases_activity of process |