General Information:

Id: 703 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Adeli K et al.(2001) Mechanisms of hepatic very low-density lipoprotein overproduction in insulin resistance. Trends Cardiovasc. Med. 11: 170-176 [PMID: 11597827]

Interaction Information:

Comment The increased flux of free fatty acids into the liver and muscles can attenuate insulin signaling and has been implicated in the exacerbation of insulin resistance.
Formal Description
Interaction-ID: 3894

drug/chemical compound

Fatty acid

affects_activity of

in liver, in muscle
Comment Patients with type 2 diabetes have impaired insulin signaling in skeletal muscle and in the liver.
Formal Description
Interaction-ID: 3900

decreases_activity of

in skeletal muscle, in liver
Comment PTP-1B can modulate insulin signaling.
Formal Description
Interaction-ID: 3902



affects_activity of

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