General Information:

Id: 6,981
Diseases: Bardet-Biedl syndrome 15 - [OMIM]
Mus musculus
article
Reference: Cui C et al.(2013) Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton PLoS Biol. 11 [PMID: 24302887]

Interaction Information:

Comment Planar cell polarity (PCP) regulates cell alignment required for collective cell movement during embryonic development. Wdpcp can regulate PCP by direct modulation of the actin cytoskeleton.
Formal Description
Interaction-ID: 68496

gene/protein

WDPCP

increases_activity of

Comment Wdpcp can regulate PCP by direct modulation of the actin cytoskeleton.
Formal Description
Interaction-ID: 68572

gene/protein

WDPCP

affects_activity of

cellular component

actin cytoskeleton

Comment Wdpcp is localized to the transition zone, and in Wdpcp-deficient cells, Sept2, Nphp1, and Mks1 were lost from the transition zone, indicating Wdpcp is required for recruitment of proteins essential for ciliogenesis.
Formal Description
Interaction-ID: 68574

gene/protein

WDPCP

affects_activity of

gene/protein

SEPTIN2

Comment Wdpcp is localized to the transition zone, and in Wdpcp-deficient cells, Sept2, Nphp1, and Mks1 were lost from the transition zone, indicating Wdpcp is required for recruitment of proteins essential for ciliogenesis.
Formal Description
Interaction-ID: 68575

gene/protein

WDPCP

affects_activity of

gene/protein

NPHP1

Comment Wdpcp is localized to the transition zone, and in Wdpcp-deficient cells, Sept2, Nphp1, and Mks1 were lost from the transition zone, indicating Wdpcp is required for recruitment of proteins essential for ciliogenesis.
Formal Description
Interaction-ID: 68578

gene/protein

WDPCP

affects_activity of

gene/protein

MKS1

Comment Wdpcp is localized to the transition zone, and in Wdpcp-deficient cells, Sept2, Nphp1, and Mks1 were lost from the transition zone, indicating Wdpcp is required for recruitment of proteins essential for ciliogenesis.
Formal Description
Interaction-ID: 68585

gene/protein

WDPCP

increases_activity of

process

cilium assembly

Comment Wdpcp is also found in the cytoplasm, where it is localized in the actin cytoskeleton and in focal adhesions. Wdpcp interacts with Sept2 and is colocalized with Sept2 in actin filaments, but in Wdpcp-deficient cells, Sept2 was lost from the actin cytoskeleton, suggesting Wdpcp is required for Sept2 recruitment to actin filaments.
Formal Description
Interaction-ID: 68586

gene/protein

WDPCP

interacts (colocalizes) with

gene/protein

SEPTIN2

Comment Wdpcp is localized to the ciliary axoneme and in a ring-like structure at the base of the cilia in IMCD3 cells. A similar distribution was observed in NIH-3T3 cells transfected with Wdpcp–FLAG, a FLAG-tagged expression vector.
Formal Description
Interaction-ID: 68587

gene/protein

WDPCP

is localized in

cellular component

axoneme

Comment In Wdpcp-Cys40 mutants Shh signaling is disrupted.
Formal Description
Interaction-ID: 68588

gene/protein

WDPCP

affects_activity of

Comment Wdpcp-Cys40 mutants show disrupted canonical Wnt signaling.
Formal Description
Interaction-ID: 68589

gene/protein

WDPCP

affects_activity of

Comment Wdpcp-Cys40 mutants showed a reduction in the expression of Wnt5a, a noncanonical Wnt ligand.
Formal Description
Interaction-ID: 68590

gene/protein

WDPCP

affects_expression of

gene/protein

WNT5A

Comment In Wdpcp-Cys40 mutants real-time PCR analysis showed an increase in Axin2 and Dishevelled (Dvl1/2/3) transcripts, while transcripts for the canonical Wnt inhibitors Dkk1/2/3 were reduced.
Formal Description
Interaction-ID: 68591

gene/protein

WDPCP

affects_expression of

gene/protein

AXIN2

Comment In Wdpcp-Cys40 mutants real-time PCR analysis showed an increase in Axin2 and Dishevelled (Dvl1/2/3) transcripts, while transcripts for the canonical Wnt inhibitors Dkk1/2/3 were reduced.
Formal Description
Interaction-ID: 68592

gene/protein

WDPCP

affects_expression of

gene/protein

DVL1

Comment In Wdpcp-Cys40 mutants real-time PCR analysis showed an increase in Axin2 and Dishevelled (Dvl1/2/3) transcripts, while transcripts for the canonical Wnt inhibitors Dkk1/2/3 were reduced.
Formal Description
Interaction-ID: 68593

gene/protein

WDPCP

affects_expression of

gene/protein

DVL2

Comment In Wdpcp-Cys40 mutants real-time PCR analysis showed an increase in Axin2 and Dishevelled (Dvl1/2/3) transcripts, while transcripts for the canonical Wnt inhibitors Dkk1/2/3 were reduced.
Formal Description
Interaction-ID: 68594

gene/protein

WDPCP

affects_expression of

gene/protein

DVL3

Comment In Wdpcp-Cys40 mutants real-time PCR analysis showed an increase in Axin2 and Dishevelled (Dvl1/2/3) transcripts, while transcripts for the canonical Wnt inhibitors Dkk1/2/3 were reduced.
Formal Description
Interaction-ID: 68595

gene/protein

WDPCP

affects_expression of

gene/protein

DKK1

Comment In Wdpcp-Cys40 mutants real-time PCR analysis showed an increase in Axin2 and Dishevelled (Dvl1/2/3) transcripts, while transcripts for the canonical Wnt inhibitors Dkk1/2/3 were reduced.
Formal Description
Interaction-ID: 68596

gene/protein

WDPCP

affects_expression of

gene/protein

DKK2

Comment In Wdpcp-Cys40 mutants real-time PCR analysis showed an increase in Axin2 and Dishevelled (Dvl1/2/3) transcripts, while transcripts for the canonical Wnt inhibitors Dkk1/2/3 were reduced.
Formal Description
Interaction-ID: 68597

gene/protein

WDPCP

affects_expression of

gene/protein

DKK3

Comment Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration.
Formal Description
Interaction-ID: 68598

gene/protein

WDPCP

increases_activity of

process

cell migration