General Information:

Id: 6,979
Diseases: Bardet-Biedl syndrome 16 - [OMIM]
Mus musculus
article
Reference: Airik R et al.(2016) SDCCAG8 Interacts with RAB Effector Proteins RABEP2 and ERC1 and Is Required for Hedgehog Signaling PLoS ONE 11 [PMID: 27224062]

Interaction Information:

Comment Sdccag8gt/gt mice exhibit developmental and structural abnormalities of the skeleton and limbs, suggesting impaired Hedgehog (Hh) signaling. Indeed, cell culture studies demonstrate the requirement of SDCCAG8 for ciliogenesis and Hh signaling.
Formal Description
Interaction-ID: 68493

gene/protein

SDCCAG8

increases_activity of

process

cilium assembly

Comment Sdccag8gt/gt mice exhibit developmental and structural abnormalities of the skeleton and limbs, suggesting impaired Hedgehog (Hh) signaling. Indeed, cell culture studies demonstrate the requirement of SDCCAG8 for ciliogenesis and Hh signaling.
Formal Description
Interaction-ID: 68532

gene/protein

SDCCAG8

increases_activity of

Comment SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, AZI1), of the endosomal sorting complex (RABEP2, ERC1), and with non-muscle myosin motor proteins (MYH9, MYH10, MYH14) at the centrosome.
Formal Description
Interaction-ID: 68534

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

OFD1

Comment SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, AZI1), of the endosomal sorting complex (RABEP2, ERC1), and with non-muscle myosin motor proteins (MYH9, MYH10, MYH14) at the centrosome.
Formal Description
Interaction-ID: 68539

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

CEP131

Comment SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, AZI1), of the endosomal sorting complex (RABEP2, ERC1), and with non-muscle myosin motor proteins (MYH9, MYH10, MYH14) at the centrosome.
Formal Description
Interaction-ID: 68542

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

RABEP2

Comment SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, AZI1), of the endosomal sorting complex (RABEP2, ERC1), and with non-muscle myosin motor proteins (MYH9, MYH10, MYH14) at the centrosome.
Formal Description
Interaction-ID: 68543

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

ERC1

Comment SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, AZI1), of the endosomal sorting complex (RABEP2, ERC1), and with non-muscle myosin motor proteins (MYH9, MYH10, MYH14) at the centrosome.
Formal Description
Interaction-ID: 68544

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

MYH9

Comment SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, AZI1), of the endosomal sorting complex (RABEP2, ERC1), and with non-muscle myosin motor proteins (MYH9, MYH10, MYH14) at the centrosome.
Formal Description
Interaction-ID: 68545

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

MYH10

Comment SDCCAG8 interacts with proteins of the centriolar satellites (OFD1, AZI1), of the endosomal sorting complex (RABEP2, ERC1), and with non-muscle myosin motor proteins (MYH9, MYH10, MYH14) at the centrosome.
Formal Description
Interaction-ID: 68546

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

MYH14

Drugbank entries Show/Hide entries for MYH14
Comment RABEP2 localization at the centrosome is regulated by SDCCAG8.
Formal Description
Interaction-ID: 68547

gene/protein

SDCCAG8

affects_quantity of

gene/protein

RABEP2

at the centrosome
Comment siRNA mediated RABEP2 knockdown in hTERT-RPE1 cells leads to defective ciliogenesis, indicating a critical role for RABEP2 in this process.
Formal Description
Interaction-ID: 68548

gene/protein

RABEP2

affects_activity of

process

cilium assembly

Comment SDCCAG8 interacts with ELKS/RAB6-interacting/CAST family member 2 (ERC2).
Formal Description
Interaction-ID: 68552

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

ERC2

Comment The study identified as SDCCAG8 interaction partners aminoacyl-tRNA synthetases (KARS, DARS) and a protein required for the assembly and stability of the aminoacyl-tRNA synthase complex (AIMP2).
Formal Description
Interaction-ID: 68554

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

KARS1

Comment The study identified as SDCCAG8 interaction partners aminoacyl-tRNA synthetases (KARS, DARS) and a protein required for the assembly and stability of the aminoacyl-tRNA synthase complex (AIMP2).
Formal Description
Interaction-ID: 68556

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

DARS1

Comment The study identified as SDCCAG8 interaction partners aminoacyl-tRNA synthetases (KARS, DARS) and a protein required for the assembly and stability of the aminoacyl-tRNA synthase complex (AIMP2).
Formal Description
Interaction-ID: 68557

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

AIMP2

Comment SDCCAG8 interacts with syntenin-1 (SDCBP), glycogenin-1 (GYG1), myosin-Ic (MYO1C), spectrin alpha chain, brain (SPTAN1), leucine-rich repeat flightless-interacting protein 2 (LRRFIP2), plectin-1 (PLEC1), and spectrin beta chain, brain 1 (SPTBN1).
Formal Description
Interaction-ID: 68558

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

SDCBP

Comment SDCCAG8 interacts with syntenin-1 (SDCBP), glycogenin-1 (GYG1), myosin-Ic (MYO1C), spectrin alpha chain, brain (SPTAN1), leucine-rich repeat flightless-interacting protein 2 (LRRFIP2), plectin-1 (PLEC1), and spectrin beta chain, brain 1 (SPTBN1).
Formal Description
Interaction-ID: 68559

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

GYG1

Drugbank entries Show/Hide entries for GYG1
Comment SDCCAG8 interacts with syntenin-1 (SDCBP), glycogenin-1 (GYG1), myosin-Ic (MYO1C), spectrin alpha chain, brain (SPTAN1), leucine-rich repeat flightless-interacting protein 2 (LRRFIP2), plectin-1 (PLEC1), and spectrin beta chain, brain 1 (SPTBN1).
Formal Description
Interaction-ID: 68560

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

MYO1C

Comment SDCCAG8 interacts with syntenin-1 (SDCBP), glycogenin-1 (GYG1), myosin-Ic (MYO1C), spectrin alpha chain, brain (SPTAN1), leucine-rich repeat flightless-interacting protein 2 (LRRFIP2), plectin-1 (PLEC1), and spectrin beta chain, brain 1 (SPTBN1).
Formal Description
Interaction-ID: 68561

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

SPTAN1

Comment SDCCAG8 interacts with syntenin-1 (SDCBP), glycogenin-1 (GYG1), myosin-Ic (MYO1C), spectrin alpha chain, brain (SPTAN1), leucine-rich repeat flightless-interacting protein 2 (LRRFIP2), plectin-1 (PLEC1), and spectrin beta chain, brain 1 (SPTBN1).
Formal Description
Interaction-ID: 68562

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

LRRFIP2

Comment SDCCAG8 interacts with syntenin-1 (SDCBP), glycogenin-1 (GYG1), myosin-Ic (MYO1C), spectrin alpha chain, brain (SPTAN1), leucine-rich repeat flightless-interacting protein 2 (LRRFIP2), plectin-1 (PLEC1), and spectrin beta chain, brain 1 (SPTBN1).
Formal Description
Interaction-ID: 68563

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

PLEC

Comment SDCCAG8 interacts with syntenin-1 (SDCBP), glycogenin-1 (GYG1), myosin-Ic (MYO1C), spectrin alpha chain, brain (SPTAN1), leucine-rich repeat flightless-interacting protein 2 (LRRFIP2), plectin-1 (PLEC1), and spectrin beta chain, brain 1 (SPTBN1).
Formal Description
Interaction-ID: 68564

gene/protein

SDCCAG8

interacts (colocalizes) with

gene/protein

SPTBN1

Drugbank entries Show/Hide entries for SPTBN1
Comment RABEP2, ERC1, and CEP131 localize to the cilia basal body.
Formal Description
Interaction-ID: 68566

gene/protein

RABEP2

is localized in

cellular component

ciliary basal body

Comment RABEP2, ERC1, and CEP131 localize to the cilia basal body.
Formal Description
Interaction-ID: 68567

gene/protein

ERC1

is localized in

cellular component

ciliary basal body

Comment RABEP2, ERC1, and CEP131 localize to the cilia basal body.
Formal Description
Interaction-ID: 68568

gene/protein

CEP131

is localized in

cellular component

ciliary basal body