General Information:

Id: 6,977
Diseases: Bardet-Biedl syndrome 19 - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
article
Reference: Yang N et al.(2015) Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis Development 142: 2194-2202 [PMID: 26023097]

Interaction Information:

Comment Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis.
Formal Description
Interaction-ID: 68420

gene/protein

IFT27

increases_activity of

Comment Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis.
Formal Description
Interaction-ID: 68421

gene/protein

IFT27

increases_activity of

Comment Disrupting Ift27 blocks the differentiation of follicular keratinocytes but not epidermal keratinocytes.
Formal Description
Interaction-ID: 68422

gene/protein

IFT27

affects_activity of

process

follicular keratinocyte differentiation

Comment Disrupting Ift27 blocks the differentiation of follicular keratinocytes but not epidermal keratinocytes.
Formal Description
Interaction-ID: 68423

gene/protein

IFT27

NOT affects_activity of

process

epidermal keratinocyte differentiation

Comment Data obtained from in vivo and in vitro experiments strongly suggest that Ift27 does not participate in ciliogenesis or ciliary maintenance in epidermal keratinocytes.
Formal Description
Interaction-ID: 68424

gene/protein

IFT27

NOT affects_activity of

process

cilium assembly

in epidermal keratinocytes
Comment The hedgehog (Hh) signaling pathway was attenuated in Ift27 mutants, which was in association with abnormal ciliary trafficking of SMO and GLI2, and impaired processing of Gli transcription factors; however, formation of the ciliary axoneme was unaffected. The ciliary localization of IFT25 (HSPB11), the binding partner of IFT27, was disrupted in Ift27 mutant cells, and Ift25-null mice displayed hair follicle phenotypes similar to those of Ift27 mutants. These data suggest that Ift27 and Ift25 operate in a genetically and functionally dependent manner during hair follicle morphogenesis.
Formal Description
Interaction-ID: 68425

gene/protein

IFT27

affects_activity of

gene/protein

SMO

via ciliary trafficking
Drugbank entries Show/Hide entries for SMO
Comment The hedgehog (Hh) signaling pathway was attenuated in Ift27 mutants, which was in association with abnormal ciliary trafficking of SMO and GLI2, and impaired processing of Gli transcription factors; however, formation of the ciliary axoneme was unaffected. The ciliary localization of IFT25 (HSPB11), the binding partner of IFT27, was disrupted in Ift27 mutant cells, and Ift25-null mice displayed hair follicle phenotypes similar to those of Ift27 mutants. These data suggest that Ift27 and Ift25 operate in a genetically and functionally dependent manner during hair follicle morphogenesis.
Formal Description
Interaction-ID: 68426

gene/protein

IFT27

affects_activity of

gene/protein

GLI2

via ciliary trafficking
Comment The hedgehog (Hh) signaling pathway was attenuated in Ift27 mutants, which was in association with abnormal ciliary trafficking of SMO and GLI2, and impaired processing of Gli transcription factors; however, formation of the ciliary axoneme was unaffected. The ciliary localization of IFT25 (HSPB11), the binding partner of IFT27, was disrupted in Ift27 mutant cells, and Ift25-null mice displayed hair follicle phenotypes similar to those of Ift27 mutants. These data suggest that Ift27 and Ift25 operate in a genetically and functionally dependent manner during hair follicle morphogenesis.
Formal Description
Interaction-ID: 68427

gene/protein

IFT27

affects_activity of

gene/protein

HSPB11