General Information:

Id: 692 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Rattus norvegicus
BTO:0000452 fibroblast
article
Reference: Nguyen DT et al.(2004) Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress Mol. Biol. Cell 15: 4248-4260 [PMID: 15201339]

Interaction Information:

Comment Tunicamycin is an activator of ER stress.
Formal Description
Interaction-ID: 3797

drug/chemical compound

Tunicamycin

increases_activity of

Comment L-Azetidine 2-carboxylic acid is an activator of ER stress.
Formal Description
Interaction-ID: 3806

drug/chemical compound

L-Azetidine 2-carboxylic acid

increases_activity of

Comment Both the affinity and the binding capacity of ER membranes for Nck1 were reduced upon Azc treatment, suggesting a dissociation of ER-membrane bound Nck1 during stress.
Formal Description
Interaction-ID: 3814

increases_dissociation of

gene/protein

ERN1

from the ER membrane
Drugbank entries Show/Hide entries for ERN1
Comment ER sress induces the activation of ERK-1 (Mapk3).
Formal Description
Interaction-ID: 3841

increases_activity of

gene/protein

MAPK3

Drugbank entries Show/Hide entries for MAPK3