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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	6,900 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Mammalia
Publication type:	review
Reference:	Maiese K(2016) Novel nervous and multi-system regenerative therapeutic strategies for diabetes mellitus with mTOR Neural Regen Res 3: 372-385 [PMID: 27127460]

Interaction Information:

Comment	Activation of mTOR signaling with p70S6K can phosphorylate IRS-1 in the renin-angiotensin-aldosterone system during consumption of high fat diets that results in high circulating angiotensin II (ANG II) and insulin resistance.
Formal Description Interaction-ID: 68067	gene/protein MTOR increases_quantity of gene/protein Angiotensin II
Drugbank entries	Show/Hide entries for MTOR
Drugbank DB00337	Pimecrolimus potentiator MTOR
Drugbank DB00877	Sirolimus inhibitor MTOR
Drugbank DB01590	Everolimus inhibitor MTOR
Drugbank DB06287	Temsirolimus inhibitor MTOR
Drugbank DB01590	Everolimus inhibitor MTOR
Drugbank DB06287	Temsirolimus inhibitor MTOR

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