General Information:

Id: 6,894 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Salameh TS et al.(2016) Insulin resistance, dyslipidemia, and apolipoprotein E interactions as mechanisms in cognitive impairment and Alzheimers disease Exp. Biol. Med. (Maywood) 241: 1676-1683 [PMID: 27470930]

Interaction Information:

Comment APOE4 knock-in mice had higher levels of blood–brain barrier (BBB) breakdown in response to injury, via upregulation of the proinflammatory cyclophilin A pathway in pericytes.
Formal Description
Interaction-ID: 67346

gene/protein mutant

APOE (isoform E4)

increases_activity of

gene/protein

PPIA

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