General Information:

Id: 6,894 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Salameh TS et al.(2016) Insulin resistance, dyslipidemia, and apolipoprotein E interactions as mechanisms in cognitive impairment and Alzheimers disease Exp. Biol. Med. (Maywood) 241: 1676-1683 [PMID: 27470930]

Interaction Information:

Comment In humans, there are three alleles of APOE: E2, E3, and E4. The APOE4 protein is folded into a more compact structure compared to the other APOE isoforms, leading to a decreased ability to bind lipids and a higher likelihood of cleavage into neurotoxic fragments. Perivascular removal of amyloid beta (Abeta) is hindered with the expression of E4, which was shown in many in vitro studies as well as in mice expressing human E4. This decreased drainage, in turn, leads to decreased clearance of Abeta peptides and increased amyloid plaques, as well as other pathophysiologic features such as alterations in the neurovascular unit and blood–brain barrier (BBB) function.
Formal Description
Interaction-ID: 67345

gene/protein mutant

APOE (isoform E4)

increases_activity of