General Information:

Id: 685 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
SN4741 cell; BTO:0003945 MN9D cell
article
Reference: Heo HY et al.(2010) LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity Exp. Cell Res. 316: 649-656 [PMID: 19769964]

Interaction Information:

Comment Overexpression of LRRK2-WT, PD-linked mutant LRRK2-G2019S in SN4741 cells cause cell death which was modestly (WT) or significantly (G2019S) increased. When these transfected cells were treated with hydrogen peroxide to mimic oxidative stress, cellular neurotoxicity was enhanced in the same order.
Formal Description
Interaction-ID: 3717

drug/chemical compound

H2O2

increases_activity of

process

neuron death

Comment Transfection of DJ-1 WT increased survival rate under hydrogen peroxide treatment regardless of whether the vector, LRRK2 WT or LRRK2-G2019S was co-transfected. However, the increase in survival rate was most remarkable in cells expressing G2019S under oxidative stress, which almost eradicated LRRK2-G2019S neurotoxicity and showed a cell survival rate similar to that of cells transfected with the control vectors.
Formal Description
Interaction-ID: 3740

gene/protein

PARK7

decreases_quantity of

drug/chemical compound

H2O2

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