General Information:

Id: 685 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
SN4741 cell; BTO:0003945 MN9D cell
article
Reference: Heo HY et al.(2010) LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity Exp. Cell Res. 316: 649-656 [PMID: 19769964]

Interaction Information:

Comment Transfection of DJ-1 WT increased survival rate under hydrogen peroxide treatment regardless of whether the vector, LRRK2 WT or LRRK2-G2019S was co-transfected. However, the increase in survival rate was most remarkable in cells expressing G2019S under oxidative stress, which almost eradicated LRRK2-G2019S neurotoxicity and showed a cell survival rate similar to that of cells transfected with the control vectors.
Formal Description
Interaction-ID: 3740

gene/protein

PARK7

decreases_quantity of

drug/chemical compound

H2O2

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