General Information:

Id: 685 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
SN4741 cell; BTO:0003945 MN9D cell
article
Reference: Heo HY et al.(2010) LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity Exp. Cell Res. 316: 649-656 [PMID: 19769964]

Interaction Information:

Comment Transfection of DJ-1 WT increased survival rate under hydrogen peroxide treatment regardless of whether the vector, LRRK2 WT or LRRK2-G2019S was co-transfected. However, the increase in survival rate was most remarkable in cells expressing G2019S under oxidative stress, which almost eradicated G2019Ss neurotoxicity and showed a cell survival rate similar to that of cells transfected with the control vectors.
Formal Description
Interaction-ID: 3733

gene/protein

PARK7

decreases_activity of

process

neuron death

induced by LRRK2-G2019S expression
Drugbank entries Show/Hide entries for PARK7