General Information:

Id: 685 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
SN4741 cell; BTO:0003945 MN9D cell
article
Reference: Heo HY et al.(2010) LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity Exp. Cell Res. 316: 649-656 [PMID: 19769964]

Interaction Information:

Comment Over-expression of LRRK2-WT and PD-linked mutant LRRK2-G2019S lead to a weak, but significant, increase in intracellular reactive oxygen species (ROS). G2019S enhances this effect.
Formal Description
Interaction-ID: 3723

gene/protein

LRRK2

increases_quantity of

drug/chemical compound

Reactive oxygen species

if overexpressed
Comment Over-expression of LRRK2-WT and PD-linked mutant LRRK2-G2019S lead to a weak, but significant, increase in intracellular reactive oxygen species (ROS). G2019S enhances this effect.
Formal Description
Interaction-ID: 3725

gene/protein mutant

LRRK2-p.G2019S

increases_quantity of

drug/chemical compound

Reactive oxygen species

amount of ROS was increased even with a higher rate than wild type