General Information:

Id: 685 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
SN4741 cell; BTO:0003945 MN9D cell
article
Reference: Heo HY et al.(2010) LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity Exp. Cell Res. 316: 649-656 [PMID: 19769964]

Interaction Information:

Comment Overexpression of LRRK2-WT, PD-linked mutant LRRK2-G2019S in SN4741 cells cause cell death which was modestly (WT) or significantly (G2019S) increased. When these transfected cells were treated with hydrogen peroxide to mimic oxidative stress, cellular neurotoxicity was enhanced in the same order.
Formal Description
Interaction-ID: 3717

drug/chemical compound

H2O2

increases_activity of

process

neuron death