General Information:

Id: 683 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Rattus norvegicus
BTO:0001009 PC-12 cell
article
Reference: Lee SY et al.(2006) PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release FASEB J. 20: 151-153 [PMID: 16394273]

Interaction Information:

Comment PS2 mutation can enhance cell vulnerability by increasing intracellular calcium levels.
Formal Description
Interaction-ID: 3786

gene/protein mutant

PSEN2-p.N141I

increases_quantity of

drug/chemical compound

Ca2+

intracellular