General Information:

Id: 683 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Rattus norvegicus
BTO:0001009 PC-12 cell
Reference: Lee SY et al.(2006) PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release FASEB J. 20: 151-153 [PMID: 16394273]

Interaction Information:

Comment Pretreatment with dantrolene 30 min before treatment with L-glutamate and Abeta(25-35) diminished the induction of apoptotic cell death in PC12/PS2mt cells treated with L-glutamate and Abeta(25-35) in a dose-dependent manne.
Formal Description
Interaction-ID: 3778

drug/chemical compound


decreases_activity of

in PC12/PS2mt cells; treated with L-glutamate and amyloid beta peptide (25-35)
Drugbank entries Show/Hide entries for Dantrolene