General Information:

Id: 6,834
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Wolfram syndrome 2 - [OMIM]
Mammalia
article
Reference: Lin CC et al.(2015) CISD2 serves a novel role as a suppressor of nitric oxide signalling and curcumin increases CISD2 expression in spinal cord injuries Injury 46: 2341-2350 [PMID: 26387034]

Interaction Information:

Comment In an animal model of spinal cord injury (SCI) the injuries were shown to reduce CISD2 mRNA and protein expression in vivo.
Formal Description
Interaction-ID: 66499

environment

spinal cord injury

decreases_expression of

gene/protein

CISD2

Comment Animals subjected to spinal cord injury (SCI) showed significant upregulation in the mRNA expression of proinflammatory mediators including iNOS and RANTES as well as downregulation in CISD2 mRNA expression compared to the controls.
Formal Description
Interaction-ID: 66519

environment

spinal cord injury

increases_expression of

gene/protein

NOS2

Drugbank entries Show/Hide entries for NOS2
Comment Animals subjected to spinal cord injury (SCI) showed significant upregulation in the mRNA expression of proinflammatory mediators including iNOS and RANTES as well as downregulation in CISD2 mRNA expression compared to the controls.
Formal Description
Interaction-ID: 66521

environment

spinal cord injury

increases_expression of

gene/protein

CCL5

Drugbank entries Show/Hide entries for CCL5
Comment Knockdown of CISD2 expression in vitro increased NO production and enhanced apoptosis.
Formal Description
Interaction-ID: 66522

gene/protein

CISD2

affects_quantity of

drug/chemical compound

NO

Comment Knockdown of CISD2 expression in vitro increased NO production and enhanced apoptosis.
Formal Description
Interaction-ID: 66523

gene/protein

CISD2

affects_activity of

Comment Lipopolysaccharide (LPS) led to a decrease in CISD2 expression and an increase in iNOS expression in vitro.
Formal Description
Interaction-ID: 66524

drug/chemical compound

Lipopolysaccharide

decreases_expression of

gene/protein

CISD2

Comment Lipopolysaccharide (LPS) led to a decrease in CISD2 expression and an increase in iNOS expression in vitro.
Formal Description
Interaction-ID: 66526

drug/chemical compound

Lipopolysaccharide

increases_expression of

gene/protein

NOS2

Drugbank entries Show/Hide entries for NOS2
Comment BCL2 mRNA expression in the lipopolysaccharide (LPS)-challenged group was significantly suppressed compared to the control group. The authors postulate that the knockdown of CISD2 expression in vitro attenuated the expression of BCL2 which subsequently enhanced neuronal apotosis.
Formal Description
Interaction-ID: 66527

drug/chemical compound

Lipopolysaccharide

decreases_expression of

gene/protein

BCL2

Drugbank entries Show/Hide entries for BCL2
Comment Curcumin reduced inflammation and upregulated CISD2 mRNA expression in vivo and in vitro 24 h after spinal cord injury (SCI).
Formal Description
Interaction-ID: 66528

drug/chemical compound

Curcumin

increases_expression of

gene/protein

CISD2

after spinal cord injury
Comment Curcumin reduced inflammation and upregulated CISD2 mRNA expression in vivo and in vitro 24 h after spinal cord injury (SCI).
Formal Description
Interaction-ID: 66529

drug/chemical compound

Curcumin

decreases_activity of

after spinal cord injury