General Information:

Id: 681
Diseases: Alzheimer disease - [OMIM]
Rattus norvegicus
BTO:0001009 PC-12 cell
article
Reference: Guo Q et al.(1996) Alzheimers PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide Neuroreport 8: 379-383 [PMID: 9051814]

Interaction Information:

Comment Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.
Formal Description
Interaction-ID: 3662

gene/protein mutant

PSEN1-p.L286V

affects_activity of

Comment Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.
Formal Description
Interaction-ID: 3667

gene/protein mutant

PSEN1-p.L286V

increases_quantity of

gene/protein

Amyloid beta peptide

Comment Hypothesis: By perturbing Ca2+ homeostasis, PS-1 mutations may sensitize neurons to Abeta-induced apoptosis.
Formal Description
Interaction-ID: 3670

none selected

Drugbank entries Show/Hide entries for or
Comment PS-1 is localized to endoplasmic reticulum (ER).
Formal Description
Interaction-ID: 3672

gene/protein

PSEN1

is localized in

cellular component

endoplasmic reticulum