General Information:

Id: 67 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Rattus norvegicus
BTO:0000991 pancreatic islet
article
Reference: Song MY et al.(2009) Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway. Toxicol. Appl. Pharmacol. 235: 57-67 [PMID: 19071154]

Interaction Information:

Comment Cytokine treatment decreased insulin secretion significantly compared to normal islets.
Formal Description
Interaction-ID: 210

gene/protein

IL1B

decreases_activity of

in pancreatic islets
Drugbank entries Show/Hide entries for IL1B
Comment Pretreatment with sulforaphane (SFN) blocked the effect of the cytokines and restored islet cell insulin secretion to levels similar to those in the controls.
Formal Description
Interaction-ID: 211

drug/chemical compound

Sulforaphane

increases_activity of

in pancreatic islets; in cytokine treated cells