General Information:

Id: 679 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Mus musculus
BTO:0004102 cerebral cortical neuron
article
Reference: West AB et al.(2007) Parkinsons disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. Hum. Mol. Genet. 16: 223-232 [PMID: 17200152]

Interaction Information:

Comment WT-LRRK2 and G2385R PD-linked mutation result in comparable cell toxicity. In contrast, PD-linked LRRK2 mutations Y1699C, G2019S and I2020T resulted in dramatic neurotoxicity 72 h post-transfection, suggesting that LRRK2 kinase activity is required for neurotoxicity.
Formal Description
Interaction-ID: 3654

gene/protein mutant

LRRK2-p.G2019S

increases_activity of

process

neuron death

with a higher rate than wild type LRRK2