General Information:
Id: | 679 (click here to show other Interactions for entry) |
Diseases: |
Parkinson disease
|
Mus musculus | |
BTO:0004102 cerebral cortical neuron | |
article | |
Reference: | West AB et al.(2007) Parkinsons disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity. Hum. Mol. Genet. 16: 223-232 [PMID: 17200152] |
Interaction Information:
Comment | WT-LRRK2 and G2385R PD-linked mutation result in comparable cell toxicity. In contrast, PD-linked LRRK2 mutations Y1699C, G2019S and I2020T resulted in dramatic neurotoxicity 72 h post-transfection, suggesting that LRRK2 kinase activity is required for neurotoxicity. |
Formal Description Interaction-ID: 3654 |
gene/protein mutant increases_activity of process |