CIDeRGeneral Information:
| Id: | 6,785 (click here to show other Interactions for entry) |
| Diseases: |
Cancer
|
| Homo sapiens | |
| BTO:0000552 HaCaT cell | |
| article/cited | |
| Reference: | Frederick JP et al.(2004) Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element Mol. Cell. Biol. 24: 2546-2559 [PMID: 14993291] |
Interaction Information:
| Comment | TGF-beta initiates its signal through binding the TGF-beta type II serine/threonine (Ser/Thr) receptor kinase, which in turn phosphorylates the type I Ser/Thr receptor, forming an activated receptor complex. The activated type I receptor is then able to phosphorylate its intracellular effector substrates, which include the highly homologous receptor Smads, Smad2 and Smad3 (cited information). |
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Formal Description Interaction-ID: 65896 |
increases_activity of gene/protein |
| Drugbank entries | Show/Hide entries for SMAD2 |