General Information:

Id: 6,747 (click here to show other Interactions for entry)
Diseases: Cardiomyopathy, diabetic
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Shah MS and Brownlee M(2016) Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes Circ. Res. 118: 1808-1829 [PMID: 27230643]

Interaction Information:

Comment The post-translational modifications of proteins called advanced glycation end-products (AGEs) are formed by glucose-derived dicarbonyls reacting with amino groups of unprotonated lysine and arginine residues of proteins. Methylglyoxal, formed by the nonenzymatic fragmentation of the glycolytic intermediate triose-phosphate, accounts for the majority of hyperglycemia-induced increase in AGE adducts in diabetic tissues.
Formal Description
Interaction-ID: 65374



increases_quantity of

drug/chemical compound

Advanced glycation end-product