General Information:

Id: 6,747 (click here to show other Interactions for entry)
Diseases: Cardiomyopathy, diabetic
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Shah MS and Brownlee M(2016) Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes Circ. Res. 118: 1808-1829 [PMID: 27230643]

Interaction Information:

Comment The post-translational modifications of proteins called advanced glycation end-products (AGEs) are formed by glucose-derived dicarbonyls reacting with amino groups of unprotonated lysine and arginine residues of proteins. Methylglyoxal, formed by the nonenzymatic fragmentation of the glycolytic intermediate triose-phosphate, accounts for the majority of hyperglycemia-induced increase in AGE adducts in diabetic tissues.
Formal Description
Interaction-ID: 65373

drug/chemical compound

Methylglyoxal

increases_quantity of

drug/chemical compound

Advanced glycation end-product

Comment The post-translational modifications of proteins called advanced glycation end-products (AGEs) are formed by glucose-derived dicarbonyls reacting with amino groups of unprotonated lysine and arginine residues of proteins. Methylglyoxal, formed by the nonenzymatic fragmentation of the glycolytic intermediate triose-phosphate, accounts for the majority of hyperglycemia-induced increase in AGE adducts in diabetic tissues.
Formal Description
Interaction-ID: 65374

phenotype

hyperglycemia

increases_quantity of

drug/chemical compound

Advanced glycation end-product

Comment In arterial endothelial cells free fatty acid-induced increase in ROS activates the same damaging pathways seen with high glucose: AGEs, PKC, the hexosamine pathway (GlcNAc), and NFkappaB. Free fatty acid–induced overproduction of superoxide also activates a variety of proinflammatory signals previously implicated in hyperglycemia-induced vascular damage, and inactivates 2 important antiatherogenic enzymes: prostacyclin synthase and eNOS.
Formal Description
Interaction-ID: 65635

phenotype

increased free fatty acid level

increases_activity of

drug/chemical compound

Advanced glycation end-product

in arterial endothelial cells