General Information:

Id: 6,731 (click here to show other Interactions for entry)
Diseases: Cancer
Lung cancer - [OMIM]
Homo sapiens
article
Reference: Wu YY et al.(2011) SCUBE3 is an endogenous TGF-beta receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer Oncogene 30: 3682-3693 [PMID: 21441952]

Interaction Information:

Comment SCUBE3 induces SMAD2 phosphorylation indicating that SCUBE3 is able to induce the TGF-beta receptor signaling.
Formal Description
Interaction-ID: 65144

gene/protein

SCUBE3

increases_activity of

in lung cancer cells H1299
Comment TGF-beta receptor signaling pathway leads to phosphorylation of SMAD2. (cited information)
Formal Description
Interaction-ID: 65146

increases_phosphorylation of

gene/protein

SMAD2

Drugbank entries Show/Hide entries for SMAD2
Comment The CUB domain of SCUBE3 interacted with the with the extracellular region of TGFbetaR-II indicating that SCUBE3 is a ligand of TGFbetaR-II and is therefore involved in TGF-beta signaling.
Formal Description
Interaction-ID: 65173

gene/protein

TGFBR2

increases_activity of

Drugbank entries Show/Hide entries for TGFBR2