General Information:

Id: 669 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1G93A transgenic mouse, transfected with human SOD1G93A
BTO:0001279 spinal cord
article
Reference: Kiaei M et al.(2007) Matrix metalloproteinase-9 regulates TNF-alpha and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis Exp. Neurol. 205: 74-81 [PMID: 17362932]

Interaction Information:

Comment Matrix metalloproteinase-9 (MMP-9) deficiency in G93A mice increased survival (31%) and significantly attenuated neuronal loss, and reduced neuronal TNF-alpha and FasL immunoreactivities in the lumbar spinal cord.
Formal Description
Interaction-ID: 3573

gene/protein

MMP9

increases_quantity of

gene/protein

TNF

in spinal cord
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