General Information:

Id: 667 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Celsi F et al.(2009) Mitochondria, calcium and cell death: a deadly triad in neurodegeneration Biochim. Biophys. Acta 1787: 335-344 [PMID: 19268425]

Interaction Information:

Comment Intra-mitochondrial Abeta was demonstrated to directly interact with cyclophilin D (CypD), the PTP (permeability transition pore) component that binds CsA and renders the channel more sensitive to Ca2+, making AD mitochondria more sensitive to PTP opening.
Formal Description
Interaction-ID: 3585

gene/protein

Amyloid beta peptide

interacts (colocalizes) with

gene/protein

PPIF

in mitochondrion
Drugbank entries Show/Hide entries for PPIF