General Information:

Id: 6,664 (click here to show other Interactions for entry)
Diseases: Friedreich ataxia 1 - [OMIM]
Mus musculus
BTO:0001263 Friend erythroleukemia cell line
article
Reference: Becker EM et al.(2002) Erythroid differentiation and protoporphyrin IX down-regulate frataxin expression in Friend cells: characterization of frataxin expression compared to molecules involved in iron metabolism and hemoglobinization Blood 99: 3813-3822 [PMID: 11986241]

Interaction Information:

Comment Intracellular Fe depletion using desferrioxamine or pyridoxal isonicotinoyl hydrazone, which chelate cytoplasmic or cytoplasmic and mitochondrial Fe pools, respectively, have no effect on frataxin expression. Furthermore, cytoplasmic or mitochondrial Fe loading of induced Friend cells with ferric ammonium citrate, or the heme synthesis inhibitor, succinylacetone, respectively, also had no effect on frataxin expression.
Formal Description
Interaction-ID: 64407

drug/chemical compound

Iron

NOT affects_expression of

gene/protein

FXN