General Information:

Id: 664 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Diabetes mellitus, type II - [OMIM]
Hypothyroidism
Insulin resistance
Mammalia
review
Reference: Coleman RA et al.(2000) Physiological and nutritional regulation of enzymes of triacylglycerol synthesis Annu. Rev. Nutr. 20: 77-103 [PMID: 10940327]

Interaction Information:

Comment In isolated islets from lean ZDF rats, leptin decreases mitochondrial GPAT and acetyl-CoA carboxylase mRNA expression 75 % - 80 %, and adding leptin to rat adipocytes decreases fatty acid synthase mRNA 90 % and increases PPARalpha mRNA twofold.
Formal Description
Interaction-ID: 3710

gene/protein

LEP

increases_expression of

gene/protein

PPARA

in adipose tissue; in lean ZDF rats
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