General Information:

Id: 664 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Diabetes mellitus, type II - [OMIM]
Hypothyroidism
Insulin resistance
Mammalia
review
Reference: Coleman RA et al.(2000) Physiological and nutritional regulation of enzymes of triacylglycerol synthesis Annu. Rev. Nutr. 20: 77-103 [PMID: 10940327]

Interaction Information:

Comment Leptin regulates lipid homeostasis in adipose tissue, lver, muscle, and pancreas by up-regulating mRNA expression of oxidative enzymes, and by stimulating fatty acid oxidation.
Formal Description
Interaction-ID: 3700

gene/protein

LEP

increases_activity of

in adipose tissue, in liver, in muscle, in pancreas, in pancreatic islet
Comment In lean ZDF rats, adenovirus-mediated hyperleptinemia markedly decreases adipose tissue mRNA expression of acetyl-CoA carboxylase, fatty acid synthase, and mitochondrial GPAT.
Formal Description
Interaction-ID: 3702

gene/protein

LEP

affects_expression of

gene/protein

ACACA

in adipose tissue; in lean ZDF rats
Drugbank entries Show/Hide entries for ACACA
Comment In lean ZDF rats, adenovirus-mediated hyperleptinemia markedly decreases adipose tissue mRNA expression of acetyl-CoA carboxylase, fatty acid synthase, and mitochondrial GPAT.
Formal Description
Interaction-ID: 3704

gene/protein

LEP

affects_expression of

gene/protein

FASN

in adipose tissue; in lean ZDF rats
Drugbank entries Show/Hide entries for FASN
Comment In lean ZDF rats, adenovirus-mediated hyperleptinemia markedly decreases adipose tissue mRNA expression of acetyl-CoA carboxylase, fatty acid synthase, and mitochondrial GPAT.
Formal Description
Interaction-ID: 3705

gene/protein

LEP

affects_expression of

gene/protein

Mitochondrial GPAT

in adipose tissue; in lean ZDF rats
Comment In isolated islets from lean ZDF rats, leptin decreases mitochondrial GPAT and acetyl-CoA carboxylase mRNA expression 75 % - 80 %, and adding leptin to rat adipocytes decreases fatty acid synthase mRNA 90 % and increases PPARalpha mRNA twofold.
Formal Description
Interaction-ID: 3707

gene/protein

LEP

decreases_expression of

gene/protein

Mitochondrial GPAT

in pancreas, in pancreatic islets; in lean ZDF rats
Comment In isolated islets from lean ZDF rats, leptin decreases mitochondrial GPAT and acetyl-CoA carboxylase mRNA expression 75 % - 80 %, and adding leptin to rat adipocytes decreases fatty acid synthase mRNA 90 % and increases PPARalpha mRNA twofold.
Formal Description
Interaction-ID: 3708

gene/protein

LEP

decreases_expression of

gene/protein

ACACA

in pancreas, in pancreatic islets; in lean ZDF rats
Drugbank entries Show/Hide entries for ACACA
Comment In isolated islets from lean ZDF rats, leptin decreases mitochondrial GPAT and acetyl-CoA carboxylase mRNA expression 75 % - 80 %, and adding leptin to rat adipocytes decreases fatty acid synthase mRNA 90 % and increases PPARalpha mRNA twofold.
Formal Description
Interaction-ID: 3709

gene/protein

LEP

decreases_expression of

gene/protein

FASN

in adipose tissue; in lean ZDF rats
Drugbank entries Show/Hide entries for FASN
Comment In isolated islets from lean ZDF rats, leptin decreases mitochondrial GPAT and acetyl-CoA carboxylase mRNA expression 75 % - 80 %, and adding leptin to rat adipocytes decreases fatty acid synthase mRNA 90 % and increases PPARalpha mRNA twofold.
Formal Description
Interaction-ID: 3710

gene/protein

LEP

increases_expression of

gene/protein

PPARA

in adipose tissue; in lean ZDF rats
Drugbank entries Show/Hide entries for PPARA