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Diseases	Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	664 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type I - [OMIM] Diabetes mellitus, type II - [OMIM] Hypothyroidism Insulin resistance
Organism:	Mammalia
Publication type:	review
Reference:	Coleman RA et al.(2000) Physiological and nutritional regulation of enzymes of triacylglycerol synthesis Annu. Rev. Nutr. 20: 77-103 [PMID: 10940327]

Interaction Information:

Comment	In lean ZDF rats, adenovirus-mediated hyperleptinemia markedly decreases adipose tissue mRNA expression of acetyl-CoA carboxylase, fatty acid synthase, and mitochondrial GPAT.
Formal Description Interaction-ID: 3704	gene/protein LEP affects_expression of gene/protein FASN in adipose tissue; in lean ZDF rats
Drugbank entries	Show/Hide entries for FASN
Drugbank DB01034	Cerulenin inhibitor FASN
Drugbank DB01083	Orlistat inhibitor FASN

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