CIDeRGeneral Information:
| Id: | 664 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type I
- [OMIM]
Diabetes mellitus, type II - [OMIM] Hypothyroidism Insulin resistance |
| Mammalia | |
| review | |
| Reference: | Coleman RA et al.(2000) Physiological and nutritional regulation of enzymes of triacylglycerol synthesis Annu. Rev. Nutr. 20: 77-103 [PMID: 10940327] |
Interaction Information:
| Comment | Leptin regulates lipid homeostasis in adipose tissue, lver, muscle, and pancreas by up-regulating mRNA expression of oxidative enzymes, and by stimulating fatty acid oxidation. |
|
Formal Description Interaction-ID: 3700 |
gene/protein increases_activity of process |
| Comment | In lean ZDF rats, adenovirus-mediated hyperleptinemia markedly decreases adipose tissue mRNA expression of acetyl-CoA carboxylase, fatty acid synthase, and mitochondrial GPAT. |
|
Formal Description Interaction-ID: 3702 |
|
| Drugbank entries | Show/Hide entries for ACACA |
| Comment | In lean ZDF rats, adenovirus-mediated hyperleptinemia markedly decreases adipose tissue mRNA expression of acetyl-CoA carboxylase, fatty acid synthase, and mitochondrial GPAT. |
|
Formal Description Interaction-ID: 3704 |
|
| Drugbank entries | Show/Hide entries for FASN |
| Comment | In lean ZDF rats, adenovirus-mediated hyperleptinemia markedly decreases adipose tissue mRNA expression of acetyl-CoA carboxylase, fatty acid synthase, and mitochondrial GPAT. |
|
Formal Description Interaction-ID: 3705 |
gene/protein affects_expression of gene/protein Mitochondrial GPAT |
| Comment | In isolated islets from lean ZDF rats, leptin decreases mitochondrial GPAT and acetyl-CoA carboxylase mRNA expression 75 % - 80 %, and adding leptin to rat adipocytes decreases fatty acid synthase mRNA 90 % and increases PPARalpha mRNA twofold. |
|
Formal Description Interaction-ID: 3707 |
gene/protein decreases_expression of gene/protein Mitochondrial GPAT |
| Comment | In isolated islets from lean ZDF rats, leptin decreases mitochondrial GPAT and acetyl-CoA carboxylase mRNA expression 75 % - 80 %, and adding leptin to rat adipocytes decreases fatty acid synthase mRNA 90 % and increases PPARalpha mRNA twofold. |
|
Formal Description Interaction-ID: 3708 |
|
| Drugbank entries | Show/Hide entries for ACACA |
| Comment | In isolated islets from lean ZDF rats, leptin decreases mitochondrial GPAT and acetyl-CoA carboxylase mRNA expression 75 % - 80 %, and adding leptin to rat adipocytes decreases fatty acid synthase mRNA 90 % and increases PPARalpha mRNA twofold. |
|
Formal Description Interaction-ID: 3709 |
|
| Drugbank entries | Show/Hide entries for FASN |
| Comment | In isolated islets from lean ZDF rats, leptin decreases mitochondrial GPAT and acetyl-CoA carboxylase mRNA expression 75 % - 80 %, and adding leptin to rat adipocytes decreases fatty acid synthase mRNA 90 % and increases PPARalpha mRNA twofold. |
|
Formal Description Interaction-ID: 3710 |
|
| Drugbank entries | Show/Hide entries for PPARA |