General Information:

Id: 664 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Coleman RA et al.(2000) Physiological and nutritional regulation of enzymes of triacylglycerol synthesis Annu. Rev. Nutr. 20: 77-103 [PMID: 10940327]

Interaction Information:

Comment Long-chain acyl-CoA synthetase (ACS) catalyzes the initial enzymatic step required for oxidation, elongation, and desaturation of fatty acids, and for the synthesis of complex lipids and acylated proteins. Tissues like liver and adipocytes express several different acyl-CoA synthetase isoforms.
Formal Description
Interaction-ID: 3555



affects_activity of

Drugbank entries Show/Hide entries for ACS
Comment Leptin regulates lipid homeostasis in adipose tissue, lver, muscle, and pancreas by up-regulating mRNA expression of oxidative enzymes, and by stimulating fatty acid oxidation.
Formal Description
Interaction-ID: 3700



increases_activity of

in adipose tissue, in liver, in muscle, in pancreas, in pancreatic islet
Comment In response to increases in the cellular AMP/ATP ratio, AMPK phosphorylates and inactivates liver acetyl-CoA carboxylase and decreases its product, malonyl-CoA, a potent inhibitor of CPT1 and beta-oxidation.
Formal Description
Interaction-ID: 3757

drug/chemical compound


decreases_activity of

in liver
Comment By decreasing malonyl-CoA, AMPK relieves the inhibition of CPT1 and thereby increases fatty acid oxidation.
Formal Description
Interaction-ID: 3761



increases_activity of

in liver; by decreasing malonyl-CoA inhibition