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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	658 (click here to show other Interactions for entry)
Diseases:	Alzheimer disease - [OMIM]
Organism:	Mammalia
Publication type:	review
Reference:	Gotz J et al.(2008) An update on the toxicity of Abeta in Alzheimers disease. Neuropsychiatr Dis Treat 4: 1033-1042 [PMID: 19337449]

Interaction Information:

Comment	Aging specifically increased the sensitivity of mitochondria to oligomeric Abeta42 damage indicating that while oligomeric and fibrillar Abeta42 are both toxic, they exert different degrees of toxicity in mitochondria from older animals.
Formal Description Interaction-ID: 3525	process aging increases_activity of phenotype amyloid beta deposits increasing the sensitivity of mitochondria to oligomeric Abeta42 damage

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