General Information:

Id: 658 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Gotz J et al.(2008) An update on the toxicity of Abeta in Alzheimers disease. Neuropsychiatr Dis Treat 4: 1033-1042 [PMID: 19337449]

Interaction Information:

Comment Aging specifically increased the sensitivity of mitochondria to oligomeric Abeta42 damage indicating that while oligomeric and fibrillar Abeta42 are both toxic, they exert different degrees of toxicity in mitochondria from older animals.
Formal Description
Interaction-ID: 3525

process

aging

increases_activity of

phenotype

amyloid beta deposits

increasing the sensitivity of mitochondria to oligomeric Abeta42 damage