General Information:

Id: 6,583 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Vieira E et al.(2014) Clock genes, pancreatic function, and diabetes Trends Mol Med 20: 685-693 [PMID: 25457619]

Interaction Information:

Comment When both Cry1 and Cry2 were deleted behavioral and molecular circadian rhythms were impaired, lipid metabolism and glucose metabolism were modified, and glucose intolerance emerged. Conversely, hepatic Cry1 overexpression in diabetic (db/db) mice led to increased insulin sensitivity and lower blood glucose levels.
Formal Description
Interaction-ID: 63483



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