General Information:

Id: 6,583 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Vieira E et al.(2014) Clock genes, pancreatic function, and diabetes Trends Mol Med 20: 685-693 [PMID: 25457619]

Interaction Information:

Comment In addition to controlling the sleep/wake and feeding cycles, the circadian system regulates physiological processes such as lipid and glucose metabolism, body temperature, locomotor activity, and hormone secretion, allowing the optimization of energy acquisition, use, and storage throughout the day.
Formal Description
Interaction-ID: 63431

affects_activity of

Comment Current lifestyle and social habits, such as eating or working at night, being exposed to artificial light at night, and altered sleeping schedules are among the factors that can cause circadian disruption. Shift workers, who are a paradigmatic model of circadian misalignment, have alterations in pancreatic beta cell responses and in glucose and lipid metabolism, as well as an increased risk of developing metabolic syndrome, cardiovascular disease, cancer, obesity, and type 2 diabetes.
Formal Description
Interaction-ID: 63460

environment

shift work

affects_activity of

Comment When both Cry1 and Cry2 were deleted behavioral and molecular circadian rhythms were impaired, lipid metabolism and glucose metabolism were modified, and glucose intolerance emerged. Conversely, hepatic Cry1 overexpression in diabetic (db/db) mice led to increased insulin sensitivity and lower blood glucose levels.
Formal Description
Interaction-ID: 63483

gene/protein

CRY1

affects_activity of

Comment When both Cry1 and Cry2 were deleted behavioral and molecular circadian rhythms were impaired, lipid metabolism and glucose metabolism were modified, and glucose intolerance emerged. Conversely, hepatic Cry1 overexpression in diabetic (db/db) mice led to increased insulin sensitivity and lower blood glucose levels.
Formal Description
Interaction-ID: 63484

gene/protein

CRY2

affects_activity of