General Information:

Id: 655 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
BTO:0004488 NSC-34 cell
article
Reference: Kupershmidt L et al.(2009) Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis FASEB J. 23: 3766-3779 [PMID: 19638399]

Interaction Information:

Comment M30 and HLA20 significantly increased phosphorylation of GSK-3-beta at Ser-9 in NSC-34 cells, suggesting that both drugs induced activation of AKT followed by phosphorylation (inactivation) of GSK-3-beta.
Formal Description
Interaction-ID: 3530

drug/chemical compound

(5-[4-propargylpiperazin-1-ylmethyl]-8-hydroxyquinoline)

increases_phosphorylation of

gene/protein

GSK3B

at Ser-9
Drugbank entries Show/Hide entries for GSK3B