General Information:

Id: 655 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
BTO:0004488 NSC-34 cell
article
Reference: Kupershmidt L et al.(2009) Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis FASEB J. 23: 3766-3779 [PMID: 19638399]

Interaction Information:

Comment M30 and HLA20 markedly increased the amount of phospho-AKT at 30 min of drug exposure.
Formal Description
Interaction-ID: 3497

drug/chemical compound

(5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline)

increases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment M30 and HLA20 markedly increased the amount of phospho-AKT at 30 min of drug exposure.
Formal Description
Interaction-ID: 3498

drug/chemical compound

(5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline)

increases_phosphorylation of

gene/protein

AKT1

at Ser-473
Drugbank entries Show/Hide entries for AKT1
Comment M30 and HLA20 markedly increased the amount of phospho-AKT at 30 min of drug exposure.
Formal Description
Interaction-ID: 3499

drug/chemical compound

(5-[4-propargylpiperazin-1-ylmethyl]-8-hydroxyquinoline)

increases_activity of

gene/protein

AKT1

Drugbank entries Show/Hide entries for AKT1
Comment M30 and HLA20 markedly increased the amount of phospho-AKT at 30 min of drug exposure.
Formal Description
Interaction-ID: 3500

drug/chemical compound

(5-[4-propargylpiperazin-1-ylmethyl]-8-hydroxyquinoline)

increases_phosphorylation of

gene/protein

AKT1

at Ser-473
Drugbank entries Show/Hide entries for AKT1