General Information:

Id: 6,542 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Cai Z et al.(2012) Roles of AMP-activated protein kinase in Alzheimers disease Neuromolecular Med. 14: 1-14 [PMID: 22367557]

Interaction Information:

Comment Resveratrol activates AMPK by increasing intracellular Ca2+ levels and by promoting AMPK phosphorylation at Thr-172 by CaMKKbeta and thus lowers Abeta levels through inhibiting mTOR to induce autophagy and then promoting intracellular degradation of Abeta by the lysosomal system in vitro. Two of resveratrol analogues, RSVA314 and RSVA405, share with resveratrol the same mechanism of action: facilitating CaMKKbeta-dependent activation of AMPK, inhibiting mTOR, and promoting autophagy and lysosomal degradation of Abeta.
Formal Description
Interaction-ID: 63631

drug/chemical compound

Resveratrol

increases_activity of

complex/PPI

AMPK

by increasing intracellular Ca2+ levels and by promoting AMPK phosphorylation at Thr-172 by CaMKKbeta.
Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol activates AMPK by increasing intracellular Ca2+ levels and by promoting AMPK phosphorylation at Thr-172 by CaMKKbeta and thus lowers Abeta levels through inhibiting mTOR to induce autophagy and then promoting intracellular degradation of Abeta by the lysosomal system in vitro. Two of resveratrol analogues, RSVA314 and RSVA405, share with resveratrol the same mechanism of action: facilitating CaMKKbeta-dependent activation of AMPK, inhibiting mTOR, and promoting autophagy and lysosomal degradation of Abeta.
Formal Description
Interaction-ID: 63755

drug/chemical compound

Resveratrol

increases_quantity of

drug/chemical compound

Ca2+

hereby activating AMPK via phosphorylation by CaMKKbeta.
Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol activates AMPK by increasing intracellular Ca2+ levels and by promoting AMPK phosphorylation at Thr-172 by CaMKKbeta and thus lowers Abeta levels through inhibiting mTOR to induce autophagy and then promoting intracellular degradation of Abeta by the lysosomal system in vitro. Two of resveratrol analogues, RSVA314 and RSVA405, share with resveratrol the same mechanism of action: facilitating CaMKKbeta-dependent activation of AMPK, inhibiting mTOR, and promoting autophagy and lysosomal degradation of Abeta.
Formal Description
Interaction-ID: 63756

drug/chemical compound

Resveratrol

increases_phosphorylation of

complex/PPI

AMPK

at Thr-172 by CaMKKbeta, hereby activating AMPK.
Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol activates AMPK by increasing intracellular Ca2+ levels and by promoting AMPK phosphorylation at Thr-172 by CaMKKbeta and thus lowers Abeta levels through inhibiting mTOR to induce autophagy and then promoting intracellular degradation of Abeta by the lysosomal system in vitro. Two of resveratrol analogues, RSVA314 and RSVA405, share with resveratrol the same mechanism of action: facilitating CaMKKbeta-dependent activation of AMPK, inhibiting mTOR, and promoting autophagy and lysosomal degradation of Abeta.
Formal Description
Interaction-ID: 63757

drug/chemical compound

Resveratrol

decreases_activity of

gene/protein

MTOR

by increasing intracellular Ca2+ levels and by promoting AMPK phosphorylation at Thr-172 by CaMKKbeta.
Drugbank entries Show/Hide entries for Resveratrol or MTOR
Comment Resveratrol activates AMPK by increasing intracellular Ca2+ levels and by promoting AMPK phosphorylation at Thr-172 by CaMKKbeta and thus lowers Abeta levels through inhibiting mTOR to induce autophagy and then promoting intracellular degradation of Abeta by the lysosomal system in vitro. Two of resveratrol analogues, RSVA314 and RSVA405, share with resveratrol the same mechanism of action: facilitating CaMKKbeta-dependent activation of AMPK, inhibiting mTOR, and promoting autophagy and lysosomal degradation of Abeta.
Formal Description
Interaction-ID: 63758

drug/chemical compound

Resveratrol

decreases_quantity of

gene/protein

Amyloid beta peptide

in vitro; via intracellular degradation of Abeta by the lysosomal system.
Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol activates AMPK by increasing intracellular Ca2+ levels and by promoting AMPK phosphorylation at Thr-172 by CaMKKbeta and thus lowers Abeta levels through inhibiting mTOR to induce autophagy and then promoting intracellular degradation of Abeta by the lysosomal system in vitro. Two of resveratrol analogues, RSVA314 and RSVA405, share with resveratrol the same mechanism of action: facilitating CaMKKbeta-dependent activation of AMPK, inhibiting mTOR, and promoting autophagy and lysosomal degradation of Abeta.
Formal Description
Interaction-ID: 63759

drug/chemical compound

Resveratrol

increases_activity of

process

autophagy

via activating AMPK.
Drugbank entries Show/Hide entries for Resveratrol
Comment Resveratrol activates AMPK by increasing intracellular Ca2+ levels and by promoting AMPK phosphorylation at Thr-172 by CaMKKbeta and thus lowers Abeta levels through inhibiting mTOR to induce autophagy and then promoting intracellular degradation of Abeta by the lysosomal system in vitro. Two of resveratrol analogues, RSVA314 and RSVA405, share with resveratrol the same mechanism of action: facilitating CaMKKbeta-dependent activation of AMPK, inhibiting mTOR, and promoting autophagy and lysosomal degradation of Abeta.
Formal Description
Interaction-ID: 63760

drug/chemical compound

Resveratrol

increases_activity of

gene/protein

CAMKK2

by increasing intracellular Ca2+ levels.
Drugbank entries Show/Hide entries for Resveratrol
Comment Melatonin potentiates the neuroprotective properties of resveratrol against Abeta-induced neurodegeneration by modulating AMPK pathways.
Formal Description
Interaction-ID: 63857

drug/chemical compound

Melatonin

increases_activity of

drug/chemical compound

Resveratrol

Drugbank entries Show/Hide entries for Melatonin or Resveratrol