General Information:

Id: 6,542 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Cai Z et al.(2012) Roles of AMP-activated protein kinase in Alzheimers disease Neuromolecular Med. 14: 1-14 [PMID: 22367557]

Interaction Information:

Comment Resveratrol activates AMPK by increasing intracellular Ca2+ levels and by promoting AMPK phosphorylation at Thr-172 by CaMKKbeta and thus lowers Abeta levels through inhibiting mTOR to induce autophagy and then promoting intracellular degradation of Abeta by the lysosomal system in vitro. Two of resveratrol analogues, RSVA314 and RSVA405, share with resveratrol the same mechanism of action: facilitating CaMKKbeta-dependent activation of AMPK, inhibiting mTOR, and promoting autophagy and lysosomal degradation of Abeta.
Formal Description
Interaction-ID: 63755

drug/chemical compound

Resveratrol

increases_quantity of

drug/chemical compound

Ca2+

hereby activating AMPK via phosphorylation by CaMKKbeta.
Drugbank entries Show/Hide entries for Resveratrol