General Information:

Id: 652 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
PS1-conditioned/PS2-conventioned double-knockout mouse, (PS1/PS2-KO)
brain
article
Reference: Chen Q et al.(2008) Loss of presenilin function causes Alzheimers disease-like neurodegeneration in the mouse. J. Neurosci. Res. 86: 1615-1625 [PMID: 18189321]

Interaction Information:

Comment Presenilin dysfunction can directly cause neurodegeneration without the involvement of beta-amyloid.
Formal Description
Interaction-ID: 3483

gene/protein mutant

PSEN1-mut

NOT affects_activity of

gene/protein

Amyloid beta peptide