General Information:

Id: 6,527
Diseases: Neurological
Mus musculus
male
Li-treated WT mice, IMPA1-KO mice, Slc5a3-KO mice, 8-week-old mice
frontal cortex
article
Reference: Toker L et al.(2014) Inositol-related gene knockouts mimic lithiums effect on mitochondrial function Neuropsychopharmacology 39: 319-328 [PMID: 23924600]

Interaction Information:

Comment The expression of the following genes was significantly changed in the same direction (upregulation or downregulation) in IMPA1-KO and in SMIT1-KO mice as well as in Li-treated WT mice as compared with their respective WT-untreated littermates: up-regulated Cox5a, Ndufab1, Ndufs7, Uqcrfs1 or down-regulated: Gaa, Gemin4, Rc3h1.
Formal Description
Interaction-ID: 62100

drug/chemical compound

Lithium

increases_expression of

gene/protein

COX5A

Drugbank entries Show/Hide entries for Lithium or COX5A
Comment The expression of the following genes was significantly changed in the same direction (upregulation or downregulation) in IMPA1-KO and in SMIT1-KO mice as well as in Li-treated WT mice as compared with their respective WT-untreated littermates: up-regulated Cox5a, Ndufab1, Ndufs7, Uqcrfs1 or down-regulated: Gaa, Gemin4, Rc3h1.
Formal Description
Interaction-ID: 62110

drug/chemical compound

Lithium

increases_expression of

gene/protein

NDUFAB1

Drugbank entries Show/Hide entries for Lithium or NDUFAB1
Comment The expression of the following genes was significantly changed in the same direction (upregulation or downregulation) in IMPA1-KO and in SMIT1-KO mice as well as in Li-treated WT mice as compared with their respective WT-untreated littermates: up-regulated Cox5a, Ndufab1, Ndufs7, Uqcrfs1 or down-regulated: Gaa, Gemin4, Rc3h1.
Formal Description
Interaction-ID: 62111

drug/chemical compound

Lithium

increases_expression of

gene/protein

NDUFS7

Drugbank entries Show/Hide entries for Lithium or NDUFS7
Comment The expression of the following genes was significantly changed in the same direction (upregulation or downregulation) in IMPA1-KO and in SMIT1-KO mice as well as in Li-treated WT mice as compared with their respective WT-untreated littermates: up-regulated Cox5a, Ndufab1, Ndufs7, Uqcrfs1 or down-regulated: Gaa, Gemin4, Rc3h1.
Formal Description
Interaction-ID: 62112

drug/chemical compound

Lithium

increases_expression of

gene/protein

UQCRFS1

Drugbank entries Show/Hide entries for Lithium or UQCRFS1
Comment The expression of the following genes was significantly changed in the same direction (upregulation or downregulation) in IMPA1-KO and in SMIT1-KO mice as well as in Li-treated WT mice as compared with their respective WT-untreated littermates: up-regulated Cox5a, Ndufab1, Ndufs7, Uqcrfs1 or down-regulated: Gaa, Gemin4, Rc3h1.
Formal Description
Interaction-ID: 62113

drug/chemical compound

Lithium

decreases_expression of

gene/protein

GAA

Drugbank entries Show/Hide entries for Lithium or GAA
Comment The expression of the following genes was significantly changed in the same direction (upregulation or downregulation) in IMPA1-KO and in SMIT1-KO mice as well as in Li-treated WT mice as compared with their respective WT-untreated littermates: up-regulated Cox5a, Ndufab1, Ndufs7, Uqcrfs1 or down-regulated: Gaa, Gemin4, Rc3h1.
Formal Description
Interaction-ID: 62114

drug/chemical compound

Lithium

decreases_expression of

gene/protein

GEMIN4

Drugbank entries Show/Hide entries for Lithium
Comment The expression of the following genes was significantly changed in the same direction (upregulation or downregulation) in IMPA1-KO and in SMIT1-KO mice as well as in Li-treated WT mice as compared with their respective WT-untreated littermates: up-regulated Cox5a, Ndufab1, Ndufs7, Uqcrfs1 or down-regulated: Gaa, Gemin4, Rc3h1.
Formal Description
Interaction-ID: 62115

drug/chemical compound

Lithium

decreases_expression of

gene/protein

RC3H1

Drugbank entries Show/Hide entries for Lithium
Comment The expression of Cox5a, Ndufab1, Ndufs7 and Uqcrfs1 is upregulated in IMPA1-KO and in SMIT1-KO mice as well as in Li-treated WT mice as compared with their respective WT-untreated littermates. All these genes are members of the mitochondrial electron transfer chain.
Formal Description
Interaction-ID: 62118

gene/protein

UQCRFS1

increases_activity of

Drugbank entries Show/Hide entries for UQCRFS1
Comment The expression of Cox5a, Ndufab1, Ndufs7 and Uqcrfs1 is upregulated in IMPA1-KO and in SMIT1-KO mice as well as in Li-treated WT mice as compared with their respective WT-untreated littermates. All these genes are members of the mitochondrial electron transfer chain.
Formal Description
Interaction-ID: 62119

gene/protein

NDUFS7

increases_activity of

Drugbank entries Show/Hide entries for NDUFS7
Comment The expression of Cox5a, Ndufab1, Ndufs7 and Uqcrfs1 is upregulated in IMPA1-KO and in SMIT1-KO mice as well as in Li-treated WT mice as compared with their respective WT-untreated littermates. All these genes are members of the mitochondrial electron transfer chain.
Formal Description
Interaction-ID: 62121

gene/protein

NDUFAB1

increases_activity of

Drugbank entries Show/Hide entries for NDUFAB1
Comment The expression of Cox5a, Ndufab1, Ndufs7 and Uqcrfs1 is upregulated in IMPA1-KO and in SMIT1-KO mice as well as in Li-treated WT mice as compared with their respective WT-untreated littermates. All these genes are members of the mitochondrial electron transfer chain.
Formal Description
Interaction-ID: 62122

gene/protein

COX5A

increases_activity of

Drugbank entries Show/Hide entries for COX5A