General Information:

Id: 6,520 (click here to show other Interactions for entry)
Diseases: Cardiomyopathy, diabetic
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Bos taurus
article
Reference: Ouslimani N et al.(2007) Metformin reduces endothelial cell expression of both the receptor for advanced glycation end products and lectin-like oxidized receptor 1 Metab. Clin. Exp. 56: 308-313 [PMID: 17292717]

Interaction Information:

Comment Stimulation of cells by advanced glycation end products (AGE)-albumin, but not by high levels of glucose, led to a sharp increase of RAGE expression. The simultaneous incubation of cells with AGE-albumin and metformin inhibited such increase in the receptor expression in a concentration-dependent manner.
Formal Description
Interaction-ID: 62010

drug/chemical compound

Advanced glycation end-product

increases_expression of

gene/protein

AGER

in aortic endothelial cells