Welcome to cider

Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	6,519 (click here to show other Interactions for entry)
Diseases:	Cardiomyopathy, diabetic Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Bos taurus
Publication type:	article
Reference:	Ouslimani N et al.(2005) Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells Metab. Clin. Exp. 54: 829-834 [PMID: 15931622]

Interaction Information:

Comment	ROS formation in Ang-stimulated cells was essentially caused by the activation of NAD(P)H oxidase and was quite completely blunted via apocynin inhibition of NAD(P)H oxidase. The combined action of apocynin and MET (metformin) led to a slightly and not significantly higher inhibition than the one of MET alone or apocynin alone. The authors conclude that the target for MET in Ang-stimulated BAEC would be NAD(P)H oxidase.
Formal Description Interaction-ID: 62001	gene/protein Angiotensin II increases_activity of complex/PPI NADPH oxidase complex in aortic endothelial cells

Home
Contact

The Helmholtz Zentrum München Imprint and Privacy Policy apply.

© 2013 - Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH) Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany

Disclaimer: IBIS Databases and associated information are protected by copyright. This server and its associated data and services are for academic, non-commercial use only. The Helmholtz Zentrum München has no liability for the use of results, data or information which have been provided through this server. Neither the use for commercial purposes, nor the redistribution of IBIS database files to third parties nor the distribution of parts of files or derivative products to any third parties is permitted. Commercial users shall contact the Helmholtz Zentrum München for a separate users license.