General Information:

Id: 6,519 (click here to show other Interactions for entry)
Diseases: Cardiomyopathy, diabetic
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Bos taurus
article
Reference: Ouslimani N et al.(2005) Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells Metab. Clin. Exp. 54: 829-834 [PMID: 15931622]

Interaction Information:

Comment ROS formation in Ang-stimulated cells was essentially caused by the activation of NAD(P)H oxidase and was quite completely blunted via apocynin inhibition of NAD(P)H oxidase. The combined action of apocynin and MET (metformin) led to a slightly and not significantly higher inhibition than the one of MET alone or apocynin alone. The authors conclude that the target for MET in Ang-stimulated BAEC would be NAD(P)H oxidase.
Formal Description
Interaction-ID: 62001

gene/protein

Angiotensin II

increases_activity of

complex/PPI

NADPH oxidase complex

in aortic endothelial cells