General Information:

Id: 6,519 (click here to show other Interactions for entry)
Diseases: Cardiomyopathy, diabetic
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Bos taurus
article
Reference: Ouslimani N et al.(2005) Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells Metab. Clin. Exp. 54: 829-834 [PMID: 15931622]

Interaction Information:

Comment Intracellular ROS (reactive oxygen species) production was measured by fluorescence of the DCF (2,7-dichlorodihydrofluorescein) probe. The results showed that metformin was able to reduce the intracellular production of ROS in both nonstimulated BAECs (-20%) and BAEC stimulated by high levels of glucose or angiotensin II (-28% and -72%, respectively).
Formal Description
Interaction-ID: 61998

gene/protein

Angiotensin II

increases_quantity of

drug/chemical compound

Reactive oxygen species

in aortic endothelial cells
Comment ROS formation in Ang-stimulated cells was essentially caused by the activation of NAD(P)H oxidase and was quite completely blunted via apocynin inhibition of NAD(P)H oxidase. The combined action of apocynin and MET (metformin) led to a slightly and not significantly higher inhibition than the one of MET alone or apocynin alone. The authors conclude that the target for MET in Ang-stimulated BAEC would be NAD(P)H oxidase.
Formal Description
Interaction-ID: 62001

gene/protein

Angiotensin II

increases_activity of

complex/PPI

NADPH oxidase complex

in aortic endothelial cells