General Information:

Id: 6,517 (click here to show other Interactions for entry)
Diseases: Metabolic
Mammalia
COS-7 cell
article
Reference: Sarkar S et al.(2005) Lithium induces autophagy by inhibiting inositol monophosphatase J. Cell Biol. 7: 1101-1111 [PMID: 16186256]

Interaction Information:

Comment Lithium induces autophagy by inhibiting inositol monophosphatase (IMPase). This leads to reduced free inositol and myo-inositol-1,4,5-triphosphate (IP3) levels.
Formal Description
Interaction-ID: 61967

drug/chemical compound

Lithium

increases_activity of

process

autophagy

via inhibiting IMPase activity resulting in lower IP3 levels
Drugbank entries Show/Hide entries for Lithium
Comment Lithium significantly reduced inositoltriphosphate (IP3) levels.
Formal Description
Interaction-ID: 61973

drug/chemical compound

Lithium

decreases_quantity of

drug/chemical compound

Inositol 1,4,5-trisphosphate

Drugbank entries Show/Hide entries for Lithium