General Information:

Id: 6,517
Diseases: Metabolic
Mammalia
COS-7 cell
article
Reference: Sarkar S et al.(2005) Lithium induces autophagy by inhibiting inositol monophosphatase J. Cell Biol. 7: 1101-1111 [PMID: 16186256]

Interaction Information:

Comment mTOR is a negative regulator of autophagy.
Formal Description
Interaction-ID: 61958

gene/protein

MTOR

decreases_activity of

process

autophagy

Drugbank entries Show/Hide entries for MTOR
Comment Autophagy is unregulated in mammalian cells by using rapamycin, which inhibits mTOR.
Formal Description
Interaction-ID: 61960

drug/chemical compound

Rapamycin

decreases_activity of

gene/protein

MTOR

Drugbank entries Show/Hide entries for MTOR
Comment Autophagy is unregulated in mammalian cells by using rapamycin, which inhibits mTOR.
Formal Description
Interaction-ID: 61966

drug/chemical compound

Rapamycin

increases_activity of

process

autophagy

Comment Lithium induces autophagy by inhibiting inositol monophosphatase (IMPase). This leads to reduced free inositol and myo-inositol-1,4,5-triphosphate (IP3) levels.
Formal Description
Interaction-ID: 61967

drug/chemical compound

Lithium

increases_activity of

process

autophagy

via inhibiting IMPase activity resulting in lower IP3 levels
Drugbank entries Show/Hide entries for Lithium
Comment Lithium significantly reduced inositoltriphosphate (IP3) levels.
Formal Description
Interaction-ID: 61973

drug/chemical compound

Lithium

decreases_quantity of

drug/chemical compound

Inositol 1,4,5-trisphosphate

Drugbank entries Show/Hide entries for Lithium
Comment Addition of myo-inositol as well as addition of the prolyl endopeptidase inhibitor 2 elevates intracellular myo-inositol-1,4,5-triphosphate (IP3). This significantly reversed the protective effect of lithium indicating that lithium regulates autophagy by reducing IP3 levels.
Formal Description
Interaction-ID: 62095

drug/chemical compound

Inositol

increases_quantity of

drug/chemical compound

Inositol 1,4,5-trisphosphate

Comment Addition of myo-inositol as well as addition of the prolyl endopeptidase inhibitor 2 elevates intracellular myo-inositol-1,4,5-triphosphate (IP3). This significantly reversed the protective effect of lithium indicating that lithium regulates autophagy by reducing IP3 levels.
Formal Description
Interaction-ID: 62105

drug/chemical compound

Inositol 1,4,5-trisphosphate

decreases_activity of

process

autophagy