General Information:

Id: 6,516 (click here to show other Interactions for entry)
Diseases: Metabolic
Homo sapiens
article
Reference: Ohnishi T et al.(2007) Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1 J. Biol. Chem. 1: 637-646 [PMID: 17068342]

Interaction Information:

Comment Lithium inhibits IMPase activity of IMPA1. However, concentrations of lithium in excess of the therapeutic range are needed to inhibit IMPase activity from IMPA2 when myo-inositol 1-monophosphate is used as a substrate. Both isoforms display a substantial different sensitivity to lithium depending on the substrates used. This indicates that myo-inositol 1-monophosphate is not the optimal substrate for IMPA2.
Formal Description
Interaction-ID: 61954

drug/chemical compound

Lithium

decreases_activity of

gene/protein

IMPA1

Sensitivity of IMPA2 to lithium is lower than sensitivity of IMPA1 to lithium.
Drugbank entries Show/Hide entries for Lithium or IMPA1
Comment Lithium inhibits IMPase activity of IMPA1. However, concentrations of lithium in excess of the therapeutic range are needed to inhibit IMPase activity from IMPA2 when myo-inositol 1-monophosphate is used as a substrate. Both isoforms display a substantial different sensitivity to lithium depending on the substrates used. This indicates that myo-inositol 1-monophosphate is not the optimal substrate for IMPA2.
Formal Description
Interaction-ID: 61956

drug/chemical compound

Lithium

decreases_activity of

gene/protein

IMPA2

Sensitivity of IMPA2 to lithium is lower than sensitivity of IMPA1 to lithium.
Drugbank entries Show/Hide entries for Lithium or IMPA2