General Information:

Id: 6,516
Diseases: Metabolic
Homo sapiens
article
Reference: Ohnishi T et al.(2007) Spatial expression patterns and biochemical properties distinguish a second myo-inositol monophosphatase IMPA2 from IMPA1 J. Biol. Chem. 1: 637-646 [PMID: 17068342]

Interaction Information:

Comment Lithium inhibits IMPase activity of IMPA1. However, concentrations of lithium in excess of the therapeutic range are needed to inhibit IMPase activity from IMPA2 when myo-inositol 1-monophosphate is used as a substrate. Both isoforms display a substantial different sensitivity to lithium depending on the substrates used. This indicates that myo-inositol 1-monophosphate is not the optimal substrate for IMPA2.
Formal Description
Interaction-ID: 61954

drug/chemical compound

Lithium

decreases_activity of

gene/protein

IMPA1

Sensitivity of IMPA2 to lithium is lower than sensitivity of IMPA1 to lithium.
Drugbank entries Show/Hide entries for Lithium or IMPA1
Comment Lithium inhibits IMPase activity of IMPA1. However, concentrations of lithium in excess of the therapeutic range are needed to inhibit IMPase activity from IMPA2 when myo-inositol 1-monophosphate is used as a substrate. Both isoforms display a substantial different sensitivity to lithium depending on the substrates used. This indicates that myo-inositol 1-monophosphate is not the optimal substrate for IMPA2.
Formal Description
Interaction-ID: 61956

drug/chemical compound

Lithium

decreases_activity of

gene/protein

IMPA2

Sensitivity of IMPA2 to lithium is lower than sensitivity of IMPA1 to lithium.
Drugbank entries Show/Hide entries for Lithium or IMPA2
Comment IMPA1 and IMPA2 dephosphorylate myo-inositol monophosphate to generate free myo-inositol. IMPA2 shows significantly lower activity toward myo-inositol monophosphate than IMPA1. Higher lithium concentrations are needed to inhibit IMPA2 than for inhibition of IMPA1.
Formal Description
Interaction-ID: 62086

gene/protein

IMPA1

increases_quantity of

drug/chemical compound

Inositol

Drugbank entries Show/Hide entries for IMPA1
Comment IMPA1 and IMPA2 dephosphorylate myo-inositol monophosphate to generate free myo-inositol. IMPA2 shows significantly lower activity toward myo-inositol monophosphate than IMPA1. Higher lithium concentrations are needed to inhibit IMPA2 than for inhibition of IMPA1.
Formal Description
Interaction-ID: 62087

gene/protein

IMPA2

increases_quantity of

drug/chemical compound

Inositol

Drugbank entries Show/Hide entries for IMPA2