General Information:

Id: 6,510 (click here to show other Interactions for entry)
Diseases: Metabolic
Ophtalmological
Mus musculus
mice with Col8a2 Q455K mutation and WT
cultured corneal endothelial cells
article
Reference: Kim EC et al.(2013) Lithium treatment increases endothelial cell survival and autophagy in a mouse model of Fuchs endothelial corneal dystrophy Br J Ophthalmol 97: 1068-1073 [PMID: 23759441]

Interaction Information:

Comment RT-PCR of lithium-treated Col8a2-Q455K endothelium showed unexpected upregulation of Caspase 12, Gsk3beta, Arrbeta2, and Impa1 versus untreated Q455K-control endothelium. However, western blotting showed the expected down regulation of Impa1 and Arrbeta2 in Q455K-lithium versus untreated Q455K-control endothelium.
Formal Description
Interaction-ID: 61908

drug/chemical compound

Lithium

increases_expression of

gene/protein

CASP12

Drugbank entries Show/Hide entries for Lithium