General Information:

Id: 6,510 (click here to show other Interactions for entry)
Diseases: Metabolic
Ophtalmological
Mus musculus
mice with Col8a2 Q455K mutation and WT
cultured corneal endothelial cells
article
Reference: Kim EC et al.(2013) Lithium treatment increases endothelial cell survival and autophagy in a mouse model of Fuchs endothelial corneal dystrophy Br J Ophthalmol 97: 1068-1073 [PMID: 23759441]

Interaction Information:

Comment RT-PCR of lithium-treated Col8a2-Q455K endothelium showed significant upregulation of autophagy markers P62, Tmem74, Tm9sf1, and Tmem166 compared to untreated Col8a2-Q455K endothelium.
Formal Description
Interaction-ID: 61884

drug/chemical compound

Lithium

increases_expression of

gene/protein

SQSTM1

Drugbank entries Show/Hide entries for Lithium
Comment RT-PCR of lithium-treated Col8a2-Q455K endothelium showed significant upregulation of autophagy markers P62, Tmem74, Tm9sf1, and Tmem166 compared to untreated Col8a2-Q455K endothelium.
Formal Description
Interaction-ID: 61887

drug/chemical compound

Lithium

increases_expression of

gene/protein

TMEM74

Drugbank entries Show/Hide entries for Lithium
Comment RT-PCR of lithium-treated Col8a2-Q455K endothelium showed significant upregulation of autophagy markers P62, Tmem74, Tm9sf1, and Tmem166 compared to untreated Col8a2-Q455K endothelium.
Formal Description
Interaction-ID: 61888

drug/chemical compound

Lithium

increases_expression of

gene/protein

TM9SF1

Drugbank entries Show/Hide entries for Lithium
Comment RT-PCR of lithium-treated Col8a2-Q455K endothelium showed significant upregulation of autophagy markers P62, Tmem74, Tm9sf1, and Tmem166 (EVA1A) compared to untreated Col8a2-Q455K endothelium.
Formal Description
Interaction-ID: 61889

drug/chemical compound

Lithium

increases_expression of

gene/protein

EVA1A

Drugbank entries Show/Hide entries for Lithium
Comment Western blot of lithium-treated Col8a2-Q455K endothelium showed significant upregulation of autophagy markers Atg5-12 compared to untreated Col8a2-Q455K endothelium.
Formal Description
Interaction-ID: 61890

drug/chemical compound

Lithium

increases_quantity of

gene/protein

ATG5

Drugbank entries Show/Hide entries for Lithium
Comment Western blot of lithium-treated Col8a2-Q455K endothelium showed significant upregulation of autophagy markers Atg5-12 compared to untreated Col8a2-Q455K endothelium.
Formal Description
Interaction-ID: 61892

drug/chemical compound

Lithium

increases_quantity of

gene/protein

ATG12

Drugbank entries Show/Hide entries for Lithium
Comment RT-PCR of lithium-treated Col8a2-Q455K endothelium showed significant upregulation of autophagy markers P62, Tmem74, Tm9sf1, and Tmem166 (EVA1A) compared to untreated Col8a2-Q455K endothelium.
Formal Description
Interaction-ID: 61893

drug/chemical compound

Lithium

increases_activity of

process

autophagy

Drugbank entries Show/Hide entries for Lithium
Comment RT-PCR of lithium-treated Col8a2-Q455K endothelium showed unexpected upregulation of Caspase 12, Gsk3beta, Arrbeta2, and Impa1 versus untreated Q455K-control endothelium. However, western blotting showed the expected down regulation of Impa1 and Arrbeta2 in Q455K-lithium versus untreated Q455K-control endothelium.
Formal Description
Interaction-ID: 61908

drug/chemical compound

Lithium

increases_expression of

gene/protein

CASP12

Drugbank entries Show/Hide entries for Lithium
Comment RT-PCR of lithium-treated Col8a2-Q455K endothelium showed unexpected upregulation of Caspase 12, Gsk3beta, Arrbeta2, and Impa1 versus untreated Q455K-control endothelium. However, western blotting showed the expected down regulation of Impa1 and Arrbeta2 in Q455K-lithium versus untreated Q455K-control endothelium.
Formal Description
Interaction-ID: 61916

drug/chemical compound

Lithium

increases_expression of

gene/protein

GSK3B

Drugbank entries Show/Hide entries for Lithium or GSK3B
Comment RT-PCR of lithium-treated Col8a2-Q455K endothelium showed unexpected upregulation of Caspase 12, Gsk3beta, Arrbeta2, and Impa1 versus untreated Q455K-control endothelium. However, western blotting showed the expected down regulation of Impa1 and Arrbeta2 in Q455K-lithium versus untreated Q455K-control endothelium.
Formal Description
Interaction-ID: 61917

drug/chemical compound

Lithium

increases_expression of

gene/protein

ARRB2

Drugbank entries Show/Hide entries for Lithium
Comment RT-PCR of lithium-treated Col8a2-Q455K endothelium showed unexpected upregulation of Caspase 12, Gsk3beta, Arrbeta2, and Impa1 versus untreated Q455K-control endothelium. However, western blotting showed the expected down regulation of Impa1 and Arrbeta2 in Q455K-lithium versus untreated Q455K-control endothelium.
Formal Description
Interaction-ID: 61918

drug/chemical compound

Lithium

increases_expression of

gene/protein

IMPA1

Drugbank entries Show/Hide entries for Lithium or IMPA1
Comment RT-PCR of lithium-treated Col8a2-Q455K endothelium showed unexpected upregulation of Caspase 12, Gsk3beta, Arrbeta2, and Impa1 versus untreated Q455K-control endothelium. However, western blotting showed the expected down regulation of Impa1 and Arrbeta2 in Q455K-lithium versus untreated Q455K-control endothelium.
Formal Description
Interaction-ID: 61919

drug/chemical compound

Lithium

decreases_quantity of

gene/protein

IMPA1

Drugbank entries Show/Hide entries for Lithium or IMPA1
Comment RT-PCR of lithium-treated Col8a2-Q455K endothelium showed unexpected upregulation of Caspase 12, Gsk3beta, Arrbeta2, and Impa1 versus untreated Q455K-control endothelium. However, western blotting showed the expected down regulation of Impa1 and Arrbeta2 in Q455K-lithium versus untreated Q455K-control endothelium.
Formal Description
Interaction-ID: 61920

drug/chemical compound

Lithium

decreases_quantity of

gene/protein

ARRB2

Drugbank entries Show/Hide entries for Lithium